All individual sera and the serum pool were tested negative for HBsAg and for antibodies against HIV-1, HIV-2 and HCV. Blood from 30 healthy donors was collected in flasks without anticoagulant and allowed to clot. Serum was collected after centrifugation and pooled in a 10-liter flask. After mixing, 1-ml aliquots of the serum were pipetted into 2-ml vials. Each vial was assigned an MBL content of 1000 AU. The material was freeze-dried and the vials closed under vacuum.
Human MBL1 is an opsonin, which activates the complement system2 on binding to microbial polysaccharides. Plasma concentrations of normally oligomerized MBL range from 0 to 7000 ng/ml and may be below 50 ng/ml in up to 12% of healthy Caucasian blood donors. Low plasma concentrations may be associated with an inherited opsonin defect3. MBL from donors of B/B genotype is poorly oligomerized and gives low readings in MBL assays selective for oligomerized MBL.
|Concentration||3200 ng/ml MBL (oligomer)|
Field marked * are mandatory and need to be filled. Please fill in an email and tel. number so we can respond to your request.